Table 5. Effects of biologics duration on adverse pregnancy outcomes.
| Outcomes | No. | Univariate analysis | Multivariate analysis | |
|---|---|---|---|---|
| Unadjusted OR (95% CIs) | Adjusted ORa (95% CIs) | |||
| Fetal loss | ||||
| Biologics naïve group | 940 | Reference | Reference | |
| Biologics use for less than one year | 104 | 1.048 (0.828–1.326) | 0.964 (0.749–1.239) | |
| Biologics use for more than one year | 153 | 0.954 (0.784–1.161) | 0.840 (0.676–1.043) | |
| Preterm delivery | ||||
| Biologics naïve group | 405 | Reference | Reference | |
| Biologics use for less than one year | 47 | 1.098 (0.796–1.513) | 1.043 (0.747–1.458) | |
| Biologics use for more than one year | 87 | 1.317 (1.027–1.689) | 1.177 (0.898–1.542) | |
| Preeclampsia/eclampsia | ||||
| Biologics naïve group | 141 | Reference | Reference | |
| Biologics use for less than one year | 21 | 1.416 (0.884–2.266) | 1.518 (0.926–2.488) | |
| Biologics use for more than one year | 15 | 0.622 (0.363–1.066) | 0.690 (0.392–1.213) | |
| Gestational diabetes mellitus | ||||
| Biologics naïve group | 1,323 | Reference | Reference | |
| Biologics use for less than one year | 117 | 0.757 (0.604–0.948) | 0.772 (0.610–0.977) | |
| Biologics use for more than one year | 184 | 0.753 (0.626–0.905) | 0.778 (0.638–0.949) | |
| Intrauterine growth retardation | ||||
| Biologics naïve group | 88 | Reference | Reference | |
| Biologics use for less than one year | 13 | 1.395 (0.772–2.522) | 1.381 (0.747–2.552) | |
| Biologics use for more than one year | 30 | 2.072 (1.357–3.164) | 2.053 (1.291–3.265) | |
| Cesarean section | ||||
| Biologics naïve group | 1,118 | Reference | Reference | |
| Biologics use for less than one year | 141 | 1.278 (1.029–1.587) | 1.146 (0.912–1.441)b | |
| Biologics use for more than one year | 226 | 1.309 (1.096–1.562) | 1.180 (0.974–1.431)b | |
CI = confidence interval, OR = odds ratio, FDA = Federal Drug Administration.
aAdjusted for recorded diagnosis, age, Charlson Comorbidity Index, previous long-term glucocorticoids use, non-steroidal anti-inflammatory drugs, and FDA category X drugs, previous history of infertility, and abortion.
bAdjusted for recorded diagnosis, age, Charlson Comorbidity Index, previous long-term glucocorticoid use, non-steroidal anti-inflammatory drugs, and FDA category X drugs, previous history of infertility, abortion, and cesarean section.