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. Author manuscript; available in PMC: 2023 Jun 7.
Published in final edited form as: Acta Neuropathol. 2022 Dec 5;145(1):1–12. doi: 10.1007/s00401-022-02521-5

Fig. 3. TSC tauopathy shows a unique pattern of immunohistochemical staining characteristics.

Fig. 3

Immunohistochemical staining performed on inferior frontal gyrus with various tau antibodies and p62 is shown in subjects with TSC tauopathy (TS 6 and TS 10). Representative images highlight immunostaining for 3R tau (RD3, a-e), 4R tau (RD4, f-i), p-tau S396–404 (PHF1, j-m), ac-tau K343 (acK343, n-r), conformational tau (MC1, s-u) and p62 (v-x). Neither TSC1 nor TSC2 subjects showed MC1 (s and t) or p62 (v and w) immunoreactivity. Positive controls are shown for MC1 (u, inferior temporal gyrus in a subject with AD) and p62 (x, cerebellum in a subject with C9orf72-FTD, to capture p62-positive dipeptide repeat protein inclusions). Boxes in panels u and x are magnified in insets. All sections were counterstained with hematoxylin. Scale bar: 100 µm in panel x and applies to all other images, 25 µm in panel r and all other insets (u, x).