Table 3.
Rescreening results: NFT burden in TSC tauopathy-vulnerable areas
| Case # | Estimated Braak stage | CP13 (p-tau, S202) | MAB359 (ac-tau, K274) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| VS | Amy | SFG | TP | VS | Amy | SFG | TP | |||
| TSC | TS 1 (TSC2) | 0 | - | - | + | - | - | - | - | - |
| TS 2 (TSC2) | 0 | - | - | - | - | - | - | - | - | |
| TS 3 (N/A) | 0 | - | - | - | - | - | - | - | - | |
| TS 4 (TSC2) | 0 | N/A | - | - | - | N/A | - | - | - | |
| TS 5 (TSC2) | 0 | - | - | - | - | - | - | - | - | |
| TS 6 (TSC1)* | 0 | N/A | - | - | - | N/A | +++ | ++ | +++ | |
| TS 7 (TSC2)* | 0 | +++ | ++ | +++ | + | +++ | ++ | +++ | ++ | |
| TS 8 (TSC2) | 0 | + | ++ | + | + | - | - | - | - | |
| TS 9 (TSC2) | 2 | + | +++ | - | +++ | + | ++ | - | ++ | |
| TS 10 (TSC2)* | 4* | ++ | +++ | +++ | ++ | ++ | +++ | +++ | +++ | |
| TS 11 (TSC2) | 1 | + | ++ | + | - | - | + | - | + | |
*
Data for the TSC tauopathy subjects reprinted from Supplementary Table 2, online resource, for ease of comparison across the TSC group.
Amy, amygdala; SFG, superior frontal gyrus; TP, temporal pole; VS, ventral striatum; N/A, not assessed.