Figure 2.

Results from the inverse-variance weighted Mendelian randomization meta-analysis between the age of natural menopause and outcomes in the Women's Health Initiative, UK Biobank and other data sources. Odds ratio for disease given a 5-year increase in age of natural menopause based on a causal genetic instrument variable analysis. 95% CI, number of individuals who were cases for the disease in each data set and analysis, and total number of individuals (cases + controls) from each data set and analysis are also shown. IVW, inverse-variance weighted; MR, Mendelian randomization; OR, odds ratio; WHI, Women’s Health Initiative; UKB, UK Biobank; NHS, Nurses Health Study; E2C2, Epidemiology of Endometrial Cancer Consortium; High density SNP analysis, High Density SNP Association Analysis of Lung Cancer; NCI GWAS, National Cancer Institute (NCI) Genome Wide Association Study (GWAS) of Lung Cancer in Never Smokers; PLCO+CSP-II GWAS, Prostate, Lung, Colon, Ovary Screening Trial + Cancer Prevention Study II; ARIC, Atherosclerosis Risk in Communities Study; CHS, Cardiovascular Health Study; FHS, Framingham Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis; WTCCC2, Wellcome Trust Case Control Consortium 2