Supplemental Table 3. Association between baseline characteristics and caediovascular mortality.

	Unadjusted model		Adjusted model
	HR [95%CI]	p value	HR [95%CI]	p value
Male	1.04 [0.65-1.66]	0.87
Age ＞75 years	1.22 [0.77-1.93]	0.40
Body mass index ＜18.5 kg/m²	2.04 [1.24-3.34]	0.005	1.50 [0.89-2.54]	0.13
Non-ambulatory status	3.19 [1.98-5.13]	＜0.001	2.13 [1.28-3.55]	0.004
Diabetes mellitus	1.22 [0.74-2.02]	0.44
Hemodialysis	5.11 [3.00-8.72]	＜0.001	3.69 [2.09-6.49]	＜0.001
Coronary artery disease	1.90 [1.21-2.98]	0.006	1.06 [0.64-1.77]	0.81
Congestive heart failure	3.85 [2.40-6.18]	＜0.001	2.15 [1.20-3.83]	0.010
Cerebrovascular disease	1.26 [0.75-2.12]	0.38
Left ventricular ejection fraction ＜50%	3.71 [2.24-6.15]	＜0.001	1.35 [0.72-2.52]	0.34
Serum albumin ＜3.0 g/dL	1.08 [0.57-2.05]	0.81
Tissue loss	2.02 [1.04-3.95]	0.039	1.44 [0.71-2.91]	0.31
EVT (versus BSX)	1.15 [0.60-2.17]	0.68
GDMT, per 1 medication increase	0.63 [0.44-0.88]	0.007	0.65 [0.43-0.99]	0.045

Hazard ratios (HRs) were presented together with the 95% confidence intervals (CIs).

GDMT = guideline-directed medical therapy.