Table 2.
The role of m7G regulators in cancer
| Molecule | Cancer | Role in cancer | Molecular Mechanism | Phenotype | Reference |
|---|---|---|---|---|---|
| RNMT | Breast cancer | + | RNMT-PI3KMUT | Proliferation, migration and tumorigenesis | [104] |
| RNMT | Glioma | + | B7-H6-c-Myc-RNMT | Proliferation, migration and tumorigenesis | [106] |
| METTL1/WDR4 | Glioblastoma | + | Arg-TCT-4-1↑/cell cycle | Proliferation, migration and tumorigenesis | [16] |
| METTL1/WDR4 | Hepatocellular carcinoma | + | PTEN↓-AKT | Proliferation and migration | [136] |
| + | CCNB1-P53/PI3K-AKT | Proliferation, migration and chemorisistance | [82] | ||
| + | m7G tRNA↑-oncogene mRNA↑ | Proliferation, migration and tumorigenesis | [67] | ||
| + | SLUG/SNAIL and TGF-β2-PMN-MDSC | tumor metastasis after (IRFA) | [85,86] | ||
| METTL1/WDR4 | Cholangio-carcinoma | + | m7G tRNA↑-oncogene mRNA↑ | Proliferation, migration and tumorigenesis | [83] |
| METTL1/WDR4 | Bladder cancer | + | EGFR↑/EFEMP | Proliferation and migration | [89] |
| METTL1/WDR4 | Cervical cancer | + | tRNA stability | Chemoresistance | [79] |
| CBC | Cervical cancer | + | CBC/ARS2-let7 | Proliferation | [68] |
| METTL1/WDR4 | Neck and head squamous cancer | + | m7G tRNA↑-PI3K-AKT-MTOR | Proliferation, migration and tumorigenesis | [87] |
| METTL1/WDR4 | Nasopharyngeal carcinoma | + | ARNT-METTL1/WDR4↑-WNT-β-catenin | Proliferation, migration, tumorigenesis and therapeutic resistance | [80] |
| METTL1/WDR4 | AML | + | Arg-TCT-4-1↑-cell cycle | Proliferation, migration and tumorigenesis | [16] |
| METTL1/WDR4 | Esophageal squamous cell carcinoma | + | MTORC1/RPTOR-ULK/autophagy | Reduced autophagy | [88] |
| METTL1/WDR4 | Lung cancer | + | tRNA function | Proliferation, migration and tumorigenesis | [77] |
| Colon cancer | - | miR-149-3p↓/S100A4↑/p53↑ | Chemoresistance | [74] | |
| METTL1/WDR4 | Lung cancer and colorectal cancer | - | let-7e↓-HMGA2/RAS/MYC↑ | Proliferation, migration and tumorigenesis | [5] |
| eIF4E | AML | + | NF-κB/eIF4E1↑ and eIF4E3↓ | Proliferation, migration and tumorigenesis | [123] |
| eIF4E | Prostate cancer | + | MTOR/Mnk1/2-eIF4E↑ | Proliferation, migration, tumorigenesis and therapeutic resistance | [96] |
| CBC (NCBP1) | Lung cancer | + | NCBP1↑-CUL4B↑ | Proliferation, migration and tumorigenesis | [111] |
(-) for suppressor gene; (+) for oncogene.