Table 1.

Pathologic phenotypes of gastric metaplasia in mouse models

Mouse model	SPEM	SPEM for Proliferation Capacity	Intestinal metaplasia	Foveolar hyperplasia	Inflammatory infiltrate	Invasive glandular production
Acute drug-induced SPEM model
Oral DMP-777 Treatment [29]	Yes	No	No	Yes	No	No
Oral high-dose tamoxifen treatmen [25,30]	Yes	No	No	Yes	Yes	No
Oral L-635 treatment [32]	Yes	Yes	No	Yes	Yes	No
gene and transcriptional manipulation mice induce SPEM model
Slc26a9fl/fl/Atp4b-Cre mice [38]	Yes	Yes	Yes	Yes	Yes	Yes
KLF4-deficient mice [39,40]	Yes	No	No	Yes	No	No
Runx3 deficient mice [43]	Yes	Yes	No	No	No	No
H/K-IFN-γ transgenic mice [47]	Yes	Yes	No	Yes	Yes	Yes
H/K-noggin transgenic mice [49]	Yes	No	No	Yes	No	No
Amphiregulin-deficient mice [14]	Yes	Yes	Yes	Yes	Yes	Yes
Gastrin-deficient mice [31]	Yes	No	No	No	No	No
Insulin-gastrin transgenic mice [63]	Yes	Yes	No	Yes	Yes	Yes
IL33-deficient mice or IL13-deficient mice [15,83]	No	No	No	No	No	No
Claudin 18-deficient mice [111]	Yes	Yes	No	No	Yes	Yes
Mist1-Kras mice [9,115]	Yes	Yes	Yes	Yes	Yes	Yes
Chronic Helicobacter infection model
H. felis or H. Pylori infection [3]	Yes	Yes	No	No	Yes	Yes