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. 2023 Apr 21;37(6):1245–1253. doi: 10.1038/s41375-023-01906-z

Fig. 5. Patterns of clonal evolution in UBTF-TD AML.

Fig. 5

Fishplots are imputed from VAFs obtained by bulk NGS at AML diagnosis and during disease progression (relapsed or refractory AML). Twelve patients with available matched samples are presented: (AJ) Relapsed AML; (KL) Refractory AML. Disappearance of all mutations (including UBTF-TD) in CR was verified by NGS (1% threshold) in patients A, B, C, and G and was assumed in the others. Details about patient history are provided in the Fig. 3. Figure made with the Fishplot package for R (version 4.2.0) [26].