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. 2023 Apr 8;37(6):1311–1323. doi: 10.1038/s41375-023-01885-1

Fig. 5. MCL-PDLS reproduces in vivo response to ibrutinib.

Fig. 5

A Tumor B-cell depletion after 72 h of ibrutinib treatment compared to untreated condition in PDLS generated from MCL patients who in vivo responded to ibrutinib (R) or patients who did not respond to the drug (NR). B B-cell viability in untreated (Ctrl) or after in vitro ibrutinib treatment (72 h) in PDLS from in vivo responder or non-responder patients. C Clinical case of MCL10 including timeline with the different lines of treatment. Graphs showed B-cell depletion and viability of PDLS after 72 h of treatment with ibrutinib refereed to untreated control.