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. 2023 May 11;26(6):1008–1020. doi: 10.1038/s41593-023-01326-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Representative transmission electron microscopy images showing the ultrastructure of ARG1^– and ARG1⁺ microglia from P13 YARG female brains in the BF/vStr. b,c, Quantitative analysis of intracellular features (b) and intracellular relationships (c; n = 3 female animals); total inclusions, P = 0.0283; empty inclusions, P = 0.0454. d, In the WT P28 BF/vStr, ARG1⁺ microglia are in close proximity to cholinergic neurons, as detected with an antibody to p75^NTR (n = 3). Scale bars, 5 μm. The yellow square indicates the location of the corresponding images below; cyan, axon terminals; red, inclusion with content; orange, empty inclusion; green, mitochondria; blue, holy mitochondria; purple, secondary lysosome; N, neuron; asterisk, endoplasmic reticulum; blue line, cell membrane; orange line, nuclear membrane. Data are shown as mean ± s.e.m. Statistically significant differences were determined by paired two-sided t-tests (for total inclusions, total inclusion with content, inclusion with axon terminal, empty inclusion, endoplasmic reticulum, contact with neuron and contact with axon terminal) or two-sided Wilcoxon matched-pairs signed-rank test (for contact with cleft); *P ≤ 0.05.

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