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. 2023 May 29;26(6):983–996. doi: 10.1038/s41593-023-01341-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a) Ponceau S staining (left) and immunoblotting (right) of sarkosyl-insoluble brain extracts (2 neurologically normal controls and 3 ALS/FTLD-TDP cases). Immunoblotting was done using rabbit polyclonal antibody specific for TMEM239. b-c) ALS/FTLD-TDP patients’ brain-derived sarkosyl-insoluble fractions analyzed in A were immunoblotted using antibodies specific for total tau (17025) and hyper-phosphorylated pathological tau (PHF-1) and specific for total α-synuclein (SNL4) or phosphorylated α-syn (81 A). Enriched tau preparations from an AD brain (AD ctrl) or α-synuclein enriched from a PD brain (PD ctrl) were used as positive controls.