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. 2023 May 29;26(6):983–996. doi: 10.1038/s41593-023-01341-4

Fig. 2. Cryo-electron microscopy of FL TDP-43 filaments unveils an amyloid core flanked by a fuzzy coat.

Fig. 2

a, Cryo-EM micrograph of FL TDP-43 filaments. b, Representative 2D class-average images (n = 186,752) extracted segments from cryo-EM micrographs of FL TDP-43 filaments with clear separation of β-strands. c, Representative 2D class-average images with a visible crossover. d, Fourier amplitudes of the 2D class-average image from c; measured helical rise was 4.75 Å. e, Representative 2D class-average images of segments (~900 Å) extracted with a large 1,000-Å box size and binned four times.