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FGFR VUS variants characterised as oncogenic or likely oncogenic using an in vitro high-throughput transformation assay (MANO method).
| Likely oncogenic | Oncogenic | |
|---|---|---|
| FGFR1 | N546K; K656E | K656M |
| FGFR2 | C62Y; N82K; E160K; E163K; Q212K; A264T; K310R; R399X; H416R; I422V; H544Q; L560F; S791T | A67V; D101Y; Y328N; G364E; V392A; E718K |
| FGFR3 | H284fs*10 | R248 S249insC; K650Q |
