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. 2023 Feb 8;47(3):333–344. doi: 10.4093/dmj.2022.0348

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Copyright © 2023 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — The intergenerational impact of gestational diabetes. Maternal hyperglycemia and resultant fetal hyperinsulinism results in developmental and epigenetic preprogramming of cardiometabolic risk in the offspring including obesity, dysglycemia, dyslipidemia, hypertension and early renal dysfunction. These risks progress to evident cardiometabolic abnormalities in adolescents and predispose young women to the development of gestational diabetes mellitus (GDM) in pregnancy, thereby restarting the cycle. T2D, type 2 diabetes mellitus.