Table 3.

Gene–environment (G × E) interactions for colorectal cancer risk based on incident cases and controls from the UK Biobank

Environmental factor	PIP4K2A rs2230469 × E interaction			HLA-DPB1 rs9277378 × E interaction			RTEL1 rs143190905 × E interaction
	β	P-value	FDR	β	P-value	FDR	β	P-value	FDR
Smoking	0.135	2.10 × 10−5	1.26 × 10−4	0.082	0.016	0.057	−7.62 × 10−5	0.999	0.999
Alcohol intake	0.118	1.41 × 10−6	2.54 × 10−5	0.117	8.35 × 10−6	7.51 × 10−5	0.104	0.063	0.095
Processed meat consumption	0.072	0.032	0.082	0.076	0.036	0.082	−0.007	0.930	0.984
BMI	0.069	3.25 × 10−4	0.047	0.067	0.075	0.104	0.162	0.052	0.084
Physical activity	0.014	0.254	0.737	0.025	0.572	0.687	−0.094	0.311	0.400
Serum vitamin D	-0.056	2.10 × 10−4	0.014	-0.050	0.044	0.085	−0.118	0.027	0.081

Adjusted for age at enrollment, sex, genotyping array, the first 10 genetic principal components and other five environment risk factors.