Table 2.

Genetic variants associated with cervical cancer in a total of 8624 cases and 400 573 controls of European ancestry (EstBB, FinnGen, UKBB+Kaiser Permanente) and 9229 cervical cancer cases and 490 304 controls in the multi-ancestry meta-analysis (EstBB, FinnGen, UKBB+Kaiser Permanente and Biobank Japan)

Variant (EA)	chr:pos (b37)	P-value European ancestry meta-analysis	P-value multi-ancestry meta-analysis	OR (95% CI) European ancestry meta-analysis	OR (95% CI) Biobank Japan dataset	EAF Eur	EAF Biobank Japan	Nearest genea
rs2268177 (T)	1:22415410	3.8 10−8	3.1 10−8	1.12 (1.07–1.16)	1.13 (1.01–1.27)	0.18	0.54	CDC42
rs4849177 (C)	2:113982584	1.3 10−15	9.4 10−15	0.87 (0.85–0.91)	0.95 (0.84–1.07)	0.39	0.35	PAX8
rs27069 (T)	5:1347128	6.1 10−15	1.3 10−14	0.88 (0.85–0.91)	0.83 (0.71–0.97)	0.43	0.14	CLPTM1L
rs35508382 (G)b	6:32593144	8.4 10−40	1.0 10−39	0.67 (0.63–0.71)	0.82 (0.70–0.97)	0.10	0.14	HLA-DQA1
rs12603332 (C)	17:38082807	1.6 10−10	1.2 10−9	0.90 (0.88–0.93)	0.96 (0.85–1.09)	0.49	0.72	ORMDL3

^aNearest gene based on Open Targets Genetics portal.

^bFor European ancestry analysis, we detected on chr6 HLA-region lead signal as rs28718232, P = 2.55 10⁻⁴⁴, but it was not a lead signal in the Biobank Japan dataset and therefore we present the common variant rs35508382 for both meta-analyses.