Fig. 1.

General overview of the study. Six cohorts of admixed Latino ancestry, representing a total of 8150 type 2 diabetes cases and 10,735 controls, were imputed with the TOPMed and 1000G Phase 3 panels (grey box). A type 2 diabetes GWAS meta-analysis of the imputed variants resulted in the identification of two novel loci, which were tested for replication in six additional Latino cohorts (green box). They were also interrogated for association with a collection of phenotypes in eight Latino cohorts (blue box) and for functional evidence in multiple available resources (purple box). The generated Latino type 2 diabetes GWAS data were used, in combination with GWAS from other ancestries, to construct ancestry-specific and multi-ancestry type 2 diabetes PSs (brown box). CMDK, Common Metabolic Disease Knowledge; sum stats, summary statistics