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. 2023 May 6;66(7):1273–1288. doi: 10.1007/s00125-023-05912-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Type 2 diabetes GWAS meta-analysis in the Latino population. (a) Manhattan plot of the meta-analysis association statistics, highlighting the loci with genome-wide significance (red) or sub-genome-wide significance (orange) for type 2 diabetes. (b) Regional association plot of the novel ORC5/LHFPL3 locus associated with type 2 diabetes risk. (c) Forest plot of the GWAS association statistics for the novel ORC5/LHFPL3 locus in the discovery (black), the replication (blue) and overall (red) cohorts