. 2023 Feb 9;396(7):1471–1485. doi: 10.1007/s00210-023-02414-8

Table 2.

Summary of the negative decadic logarithms of EC₅₀ values (= pD2 values) in atrial preparations from 5-HT₄-TG. Data are separated according to the tissue tested: either left or right atrium of 5-HT₄-TG. Number of animals ranged from 4 to 7

Tissue	Parameter	5-HT	Bufotenin	Tryptamine	Tryptamine + pargyline
LA	Force of contraction	7.94 ± 0.32 N = 4	6.77 ± 0.52 * N = 5	4.57 ± 0.92 *^# N = 5	5.48 ± 0.64 *^# N = 5
LA	TTP	8.07 ± 0.24 N = 5	6.45 ± 0.47 * N = 5	5.18 ± 0.53 *^# N = 5	6.12 ± 0.38 *⁺ N = 5
LA	TR	8.62 ± 0.83 N = 4	6.31 ± 1.65 * N = 5	5.54 ± 0.87 * N = 5	6.45 ± 0.99 N = 5
LA	dF/dt_max	7.87 ± 0.25 N = 4	6.9 ± 0.73 * N = 5	4.73 ± 0.89 *^# N = 7	5.47 ± 0.59 *^# N = 5
LA	dF/dt_min	7.91 ± 0.34 N = 4	6.92 ± 0.7 * N = 5	4.73 ± 0.79 *^# N = 7	5.51 ± 0.45 *^#+ N = 5
RA	Beating rate	7.05 ± 5.02 N = 4	7.04 ± 1.08 N = 6	5.27 ± 0.53 *^# N = 5	5.98 ± 1.63 * N = 5

Tissue

Parameter

5-HT

Bufotenin

Tryptamine

Tryptamine + pargyline

Force of contraction

7.94 ± 0.32

N = 4

6.77 ± 0.52 *

N = 5

4.57 ± 0.92 *^#

N = 5

5.48 ± 0.64 *^#

N = 5

TTP

8.07 ± 0.24

N = 5

6.45 ± 0.47 *

N = 5

5.18 ± 0.53 *^#

N = 5

6.12 ± 0.38 *⁺

N = 5

8.62 ± 0.83

N = 4

6.31 ± 1.65 *

N = 5

5.54 ± 0.87 *

N = 5

6.45 ± 0.99

N = 5

dF/dt_max

7.87 ± 0.25

N = 4

6.9 ± 0.73 *

N = 5

4.73 ± 0.89 *^#

N = 7

5.47 ± 0.59 *^#

N = 5

dF/dt_min

7.91 ± 0.34

N = 4

6.92 ± 0.7 *

N = 5

4.73 ± 0.79 *^#

N = 7

5.51 ± 0.45 *^#+

N = 5

Beating rate

7.05 ± 5.02

N = 4

7.04 ± 1.08

N = 6

5.27 ± 0.53 *^#

N = 5

5.98 ± 1.63 *

N = 5

LA left atrium, RA right atrium, TTP time to peak, TR time of relaxation, dF/dt maximum and minimum of the first derivative of force of contraction. ANOVA: *p < 0.05 vs. 5-HT; ^#p < 0.05 vs. bufotenin; ⁺p < 0.05 vs. tryptamine