Fig. 1.

Experimental design of mouse glycaemic clamps. (a) Control (A, B, C) and Nrf2^−/− (G, H, I) mice were exposed to stable euglycaemia (WT- or Nrf2^−/−-EE), hypoglycaemia (~ 2.8 mmol/l) with recovery to euglycaemia (~5.2 mmol/l) (WT- or Nrf2^−/−-LE), or hypoglycaemia with recovery to hyperglycaemia (>16 mmol/l) (WT- or Nrf2^−/−-LH). (b) STZ-diabetic (D, E, F) mice were exposed to stable hyperglycaemia (STZ-HH), hypoglycaemia with recovery to hyperglycaemia (STZ-LH), or hypoglycaemia with recovery to euglycaemia (STZ-LE)