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. 2023 Jun 6;14:3303. doi: 10.1038/s41467-023-38429-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c Examples of simulated chromatin segments for chr7: 39.5–42.5 Mb, chr7: 95.4–96.5 Mb and chr9: 107.5–110.5 Mb. Each segment is shown with the experimental Hi-C map (left) and a representation of the structures (middle) that were used to build the simulated distance map (right) at 1 kb resolution. The circle and line indicate compartmental features near the diagonal captured by the simulation. d, e Examples modeling genes with discordant compartments are shown for TMEM38B in chromosome 9 and SEM1 in chromosome 7.