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. 2023 Jun 6;14:3303. doi: 10.1038/s41467-023-38429-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Hi-C map compared to MiChroM in PGP1f cells. Arrow indicates a locus with ambiguous eigenvector values, which MiChroM had difficulty predicting. b Distance normalized Hi-C map of PGP1f cells, with the imaged segments denoted. Rectangle highlights the section modeled by MiChroM. c Median eigenvector within each imaged segment (y-axis) compared to the relative percent of images where that location was in A vs. B by OligoSTORM (x-axis). The line represents a linear fit, R² = 0.91, while the shaded area is a fit encompassing all data points. d The imaging-based compartment status in single chromosomes. Heatmap represents the A or B designation of each imaged segment (columns) based on spatial and volumetric features of individual chromosomes in single cells (rows). On the sides are representative images of the corresponding genomic segments. Below are the percentage of individual chromosomes where the imaging reflects A vs. B compartment segments compared to the median eigenvector. Source data are provided as a Source Data file. e Representative images of the entire region colored by the A/B designation of each imaged segment. MichroM model parameters are included in Source Data.