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. 2023 Jun 6;13:9172. doi: 10.1038/s41598-023-36266-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TNFα is increased in MPN patients and inversely correlated with platelet mitochondrial mass. (A) The concentration of TNFα measured in plasma samples was higher in MPN patients than in healthy donors (median and 95% CI). (B) In MPN patients there was an inverse correlation between TNFα concentration and platelet mitochondrial mass (assessed as total number of mitochondria in 50 platelets in TEM images). Healthy donors (black circles), ET (squares), PV (diamonds), PMF (triangles), JAK2 V617F (red), CALR (blue), triple negative (green). P < 0.05 (*), Pearson correlation, P < 0.01 (**).