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. 2023 Jun 6;13:9172. doi: 10.1038/s41598-023-36266-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MPN platelet mitochondria are hypersensitive to depolarization following stimulation with thrombin. (A, B) Dose–response curves derived from stimulation with various concentrations of thrombin (A) or thrombin with collagen (10 µg/mL) (B) in healthy donors (n = 20) or ET (n = 35) and PV (n = 9) patients. Error bars for each point represent differences between individuals. Data analysis was by a mixed-effects 2-way ANOVA followed by Tukey’s multiple comparisons test. P < 0.05 (*), P < 0.01 (**) = significant, ns = not significant. (C) TMRE staining of mitochondria of healthy donors (n = 19–20), ET (n = 31–36) and PV (n = 9–11) patients under resting conditions, and following stimulation with ADP (5 mg/mL), collagen (10 µg/mL), or CRP-XL (1 µg/mL) alone. Column graphs showing error bars represent differences between individual subjects. Data were analysed using a one-way ANOVA or Kruskal–Wallis test. P < 0.05 (*) = significant, ns = not significant.