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. 2023 Jun 6;13:9172. doi: 10.1038/s41598-023-36266-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Platelet mitochondria from MPN patients are located nearer the surface membrane than in healthy donors. (A) Distance of mitochondria from the surface membrane (μm) was standardized by dividing by the mean platelet radius in platelets from healthy donors (n = 10) and MPN patients (n = 13). Box–Whisker plots showing the max, min, interquartile range, median and mean ( +) represent individual subject means. Mann–Whitney Test. P < 0.001 (***). (B) Representative confocal microscopy images showing differences in mitochondrial location in a healthy donor (i) and an MPN patient (ii).