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. 2023 Apr 8;30(6):1404–1415. doi: 10.1038/s41418-023-01159-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Exposure of human to famine, i.e. nutrient deprivation, is linked to transgenerational effects on health span and longevity in their offspring. Nutrient starvation-induced autophagy is associated to modifications of the chromatin, including DNA methylation and histone posttranslational modifications (including H3K4me3, H3K9me3, H3R17me2, H3K27me3/ac, H3K56ac, H4K16ac and H4K20me3), some of which are reported to contribute to transgenerational epigenetic inheritance. Hence, an epigenetic memory of autophagy could contribute to food deprivation induced effects across successive generations. The image was created with BioRender.com.