Table 2.
MIC reading after 7 days of incubation.
| Strain | Mutation | Repeat | BDQ concentration (µg/ml) | MIC | BDQ phenotype* | |||
|---|---|---|---|---|---|---|---|---|
| 0.125 | 0.25 | 0.5 | 1.0 | |||||
| C14 | atpE Ile66Val | 1 | R | R | S | S | 0.5 | Susceptible |
| 2 | R | R | S | S | 0.5 | Susceptible | ||
| 3 | R | S | S | S | 0.25 | Susceptible | ||
| C15 | Rv0678 Thr33Ala | 1 | R | R | R | R | > 1.0 | Resistant |
| 2 | R | R | R | R | > 1.0 | Resistant | ||
| 3 | R | R | R | R | > 1.0 | Resistant | ||
| C46 | Rv0678 Thr33Ala | 1 | R | R | R | R | > 1.0 | Resistant |
| 2 | R | R | R | R | > 1.0 | Resistant | ||
| 3 | R | R | R | R | > 1.0 | Resistant | ||
| H37Rv | Wild type | 1 | R | S | S | S | 0.25 | Susceptible |
| 2 | R | R | S | S | 0.5 | Susceptible | ||
| 3 | R | S | S | S | 0.25 | Susceptible | ||
| Resistant control | atpE Ala63Pro | 1 | R | R | R | R | > 1.0 | Resistant |
| 2 | R | R | R | R | > 1.0 | Resistant | ||
| 3 | R | R | R | R | > 1.0 | Resistant | ||
BDQ bedaquiline, MIC minimal inhibitory concentration, R resistant, S susceptible.
*Based on 1.0 µg/ml cut-off.