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. 2023 Jun 7;3:57. doi: 10.1038/s43705-023-00263-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representation of the PMC627.10 A. gracile genome displaying from the inner to the outer circle: (i) the coding DNA sequence (CDS) on both strands with biosynthetic gene clusters (BGCs) in black, (ii) frequency (%) of CDS-associated clusters of orthologous genes (COGs) in the four A. gracile genomes, (iii) the synteny index, and (iv) the largest (>10kb) assembled scaffolds representing >99% of the genome. b Venn diagram of the distribution of COGs and singletons with white labels. c Percentage of COG functional categories with significant differences (Student’s t test with p < 0.01) between core (white) and flexible (red) gene sets, including a focus on the “Replication, Recombination and Repair” COG category (L). COG categories: B-“Chromatin structure/dynamics", C-“Energy production/conversion", E-“Amino acid metabolism/transport", F-“Nucleotide metabolism/transport", G-“Carbohydrate metabolism/transport", H-“Coenzyme metabolism", I-“Lipid metabolism", J-“Translation", O-“Post-translational modification/protein turnover/chaperone functions", P-“Inorganic ion transport/metabolism", Q-“Secondary metabolism", and S-“Function unknown". d Presence or absence of BGCs (COG category Q) among A. gracile strains and closed Nostocales taxa gathered by BGC types (‘-‘, uncharacterized product). The solid circles indicate BGCs whose products have been formally identified by mass spectrometry. Left: Phylogenomic tree (see Supplementary Methods and Table S1 for the list of genes used). Right: histogram displaying the number of BGCs by strain colored by BGC type. NRPS/PKS non-ribosomal peptide synthetase/polyketide synthetase, RiPPs ribosomally synthesized, post-translationally modified peptides, terpenes and others (uncharacterized). The lists of BGC and analytes detected in each strain can be found in Supplementary Tables S2 and S3, respectively.