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. 2023 Jun 6;11(11):e15701. doi: 10.14814/phy2.15701

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© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proteomic adaptations of the M. plantaris. (a, b) Volcano plots showing the differentially regulated proteins in Run and RR compared to sedentary mice. (c) Venn's diagram showing the overlap between upregulated (p _unadjusted < 0.01) proteins in Run and RR compared to Sed along with (d) their UniProt‐based subcellular localization (PM: plasma membrane) and (e) Circos plots connecting the same proteins (purple lines) or proteins belonging to the same ontology term (blue lines). Heatmaps generated with Metascape showing (f) the top enriched ontology terms of upregulated proteins and (g) transcription factors/coregulators regulating these proteins as well as (h) top enriched ontology terms of significantly (p _unadjusted < 0.01) downregulated proteins. n = 4 for all datasets.