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. 2023 May 24;10:1144677. doi: 10.3389/fnut.2023.1144677

Table 2.

Nanoencapsulation of polyphenolic compounds polysaccharide and protein-based nanostructures.

Encapsulating material Phenolic compound Method Size (nm) Zeta potential (mV) Encapsulation efficiency (%) Purpose Reference
Pectin - Cellulose A blend of phenolic compounds extracted from pomegranate peel Nanoemulsion ~200 – ~20 Highest antimicrobial activity (220)
Carboxymethyl chitosan Epigallocatechin gallate Ionic cross-linking 400 +36.6 75 Increase antitumor activity (222)
Pectin – WPC Olive leaf phenolic compounds Nanoemulsion 347.7 – 72.73 to 96.64 Increased antioxidant properties and release rate (205)
Pectin – WPI Anthocyanin Self-assembly 200 −36 55 Improve Stability (184)
Carboxymethyl chitosan Anthocyanin Ionic interaction 219.53 – 63.15 Promote stability and inhibit degradation in the gastrointestinal tract (224)
Chitosan Catechins Polyanion-gelation 169.0 to 201.4 ~ +30 24 to 53 Targeted delivery system (225)
Chitosan and β-lactoglobulin Epigallocatechin gallate Ionic gelation 100 to 500 +10 to +35 ~ 60 To release epigallocatechin gallate in the gastrointestinal tract (226)
Chitosan-Alginate Anthocyanins Ionic pre-gelation and polyelectrolyte complex formation 358.5 to 635.9 – 56.87 to 68.9 Maintenance of antioxidant activity (227)
Chitosan Anthocyanin Ionic gelation 160 to 1,093 – – To stabilize the color and the antioxidant activity (228)
Chitosan - β-Lactoglobulin Anthocyanin Ionic gelation 91,71 – 69.33 To improve stability and bioavailability (223)
Soybean insoluble dietary fiber Anthocyanin (Malvidin-3-O-glucoside) Emulsification 300 – – Storage stability and protection of color (229)
Chitosan Anthocyanin Ionotropic gelation 274 to 455 −5.04 to −35.4 70 To improve in vivo antioxidant potential (230)
Pectin Resveratrol Antisolvent precipitation and electrostatic deposition 120 −30 – Stability, Bioaccessibility, and Antioxidant Capacity Maintenance (218)
Pectin–Chitosan Anthocyanins Self-assembly 100–300 – 66.68 Molecular Stability and Control Released (215)
Pectin–Lysozyme Anthocyanins Self-assembly 198.5 −26 73 Molecular Stability (18)
Chitosan–Pectin Anthocyanin Polyelectrolyte complex – + 37 to +55.5 60 Color protection and application in food packaging (221)
Pectin-Chitosan Anthocyanin Nanoliposomes 64 to 352 −30 to +21 28.54 to 61.17 To investigate the protective effect of hepatocytes injury in L02 cells (231)
Hohenbuehelia serotina polysaccharides Quercetin Self-assembly 360 −38.8 21.41 to 52.28 Maintenance of stability and its anti-proliferative activities during in vitro gastrointestinal digestion (232)
Chitosan - β-Lactoglobulin Anthocyanin Ionic gelation 580.4 +49.6 77.4 Storage stability and oxidant stability during in vitro simulated digestion (233)
Zein–Carboxymethyl cellulose Quercetin and Resveratrol Antisolvent Precipitation 217 −33.6 to −45.6 25,1 Thermal stability and orally administered (234)

WPI, Whey Protein Isolate; WPC, Whey Protein Concentrate.