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. 2023 May 24;16:1092913. doi: 10.3389/fnmol.2023.1092913

Figure 2.

Figure 2

Circularisation of endogenous ADAR using autocatalytic twister ribozymes. Twister ribozymes rapidly self-cleave after transcription has occurred. RNA hybridization brings the unique 5’ and 3’ ends in close proximity for the ligation by the ubiquitously expressed RNA ligase RtbC.