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. 2023 May 24;17:1180825. doi: 10.3389/fncel.2023.1180825

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Copyright © 2023 Shafqat, Albalkhi, Magableh, Saleh, Alkattan and Yaqinuddin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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This figure depicts the composition of different compartments of the SCI lesion site. The fibrotic scar mainly comprises stromal cells, blood-borne inflammatory cells, and microglia. This core is surrounded by glial scar, composed of an astrocyte limitans border, oligodendrocyte progenitor cells (OPCs), and microglia. Extensive reactive changes also take place in the adjacent neural parenchyma, including axonal dieback and synaptic remodeling and axonal sprouting of spared axons. Glial cells such as astrocytes, OPCs and microglia in this peri-lesional area are reactive, but differ in their magnitude of reactivity than those at the lesion site. This figure was created with Biorender.com.