Table 1.
General information of patients and comparison of effective rate of PER in different variables at 6 months of follow-up.
| Index | Total (n = 62) | Effective (n = 49) | Noneffective (n = 13) | p-value |
|---|---|---|---|---|
| Age (year) | 6.71 ± 3.01 | 7.07 ± 2.92 | 5.36 ± 3.10 | >0.05 |
| Sex | ||||
| Male | 39 (62.9%) | 30 (76.9%) | 9 (23.1%) | >0.05 |
| Female | 23 (37.1%) | 19 (82.6%) | 4 (17.4%) | |
| Weight (kg) | 22.50 (17.50, 34.13) | 23.00 (17.75, 35.50) | 21.00 (15.00, 25.25) | >0.05 |
| Onset age of PER (year) | 6.63 (4.15, 9.00) | 7.00 (4.30, 9.00) | 5.00 (2.88, 7.00) | >0.05 |
| Duration of epilepsy (month) | 4.50 (2.00, 12.25) | 5.00 (3.00, 12.50) | 3.00 (0.40, 10.00) | >0.05 |
| Seizure frequency at baseline (monthly) | 2.00 (1.00, 4.00) | 2.00 (1.00, 4.00) | 4.00 (1.00, 34.00) | >0.05 |
| Etiology | ||||
| Genetic | 35 (56.5%) | 32 (91.4%) | 3 (8.6%) | >0.05 |
| Structural | 14 (22.6%) | 7 (50.0%) | 7 (50.0%) | |
| Encephalomalacia foci | 6 (9.7%) | 4 (66.7%) | 2 (33.3%) | |
| MCD | 8 (12.9%) | 3 (37.5%) | 5 (62.5%) | |
| Unknown | 13 (20.9%) | 10 (76.9%) | 3 (23.1%) | |
| Epileptic syndrome | ||||
| SeLECTs | 23 (37.1%) | 21 (91.3%) | 2 (8.7%) | >0.05 |
| COVE | 6 (9.7%) | 5 (83.3%) | 1 (16.7%) | |
| SHE | 2 (3.2%) | 1 (50.0%) | 1 (50.0%) | |
| SeLEAS | 4 (6.5%) | 4 (100%) | 0 | |
| Unknown | 27 (43.5%) | 18 (66.7%) | 9 (33.3%) | |
| Maintenance dose of PER (mg/day) | 4.00 (2.00, 4.00) | 4.00 (2.00, 4.00) | 4.00 (3.50, 5.50) | >0.05 |
PER, perampanel; MCD, malformations of cortical development; SeLECTs, self-limiting epilepsy with centrotemporal spikes; SHE, sleep-related hypermotor epilepsy; COVE, childhood occipital visual epilepsy; SeLEAS, self-limited epilepsy with autonomic seizures.