Fig. 5.

[¹⁸F]FEPPA (V_T) in the prioritized ROIs among inflammatory clusters in the entire cohort and CHR group

Fig. 5. The scatter dot plot graph reflects [¹⁸F]FEPPA regional binding (V_T) in prioritized ROIs (i.e., DLPFC and hippocampus) among the three inflammatory clusters (low, intermediate and elevated cytokine cluster) in the entire cohort (A) and two inflammatory clusters (low and elevated cytokine cluster) in the CHR group (B). Horizontal bar indicates group mean adjusted for TSPO rs6971 genotype and BMI using the estimated marginal means of each region.

Abbreviations: CHR - Clinical high risk; DLPFC - dorsolateral prefrontal cortex; [¹⁸F]FEPPA - fluorine F 18–labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide; mL/cm³ – milliliter/cubic centimetre; V_T - total volume of distribution.