Table 2.
Single and paired-pulsed TMS comparison between patient groups and HC.
| Examination | TRA-RBD (n = 7) | TRN-RBD (n = 7) | HC (n = 8) | Mann–Whitney U test p-value |
Kruskal Wallis Test p-value |
||
|---|---|---|---|---|---|---|---|
| TRA vs. TRN | TRA vs. HC | TRN vs. HC | |||||
| RMT (%) | 62.7 ± 10.0 | 69.0 ± 11.05 | 65.88 ± 14.317 | 0.318 | 0.817 | 0.685 | 0.647 |
| AMT (%) | 48.4 ± 12.2 | 55.1 ± 13.2 | 44.25 ± 9.362 | 0.128 | 0.485 | 0.131 | 0.179 |
| MEP amplitude (mV) | |||||||
| Rest, 100% RMT | 0.23 ± 0.22 | 0.09 ± 0.09 | 0.10 ± 0.06 | 0.085 | 0.064 | 0.418 | 0.100 |
| Rest, 110% RMT | 0.45 ± 0.53 | 0.33 ± 0.42 | 0.371 ± 0.24 | 0.277 | 0.643 | 0.487 | 0.584 |
| 50% MVC, 110% RMT | 1.28 ± 0.78 | 3.33 ± 2.63 | n.a. | 0.142 | n.a. | n.a. | n.a. |
| 100% MVC, 110% RMT | 2.43 ± 2.13 | 5.28 ± 3.04 | n.a. | 0.142 | n.a. | n.a. | n.a. |
| SICI ratio (ISI 3 ms, %) | 98.6 ± 28.3*,† | 70.2 ± 32.3† | 53.4 ± 10.9† | 0.064 | 0.008 | 0.105 | 0.012 |
| ICF ratio (ISI 10 ms, %) | 168.6 ± 76.2* | 180.2 ± 118.9 | 112.9 ± 16.2 | 0.565 | 0.037 | 0.247 | 0.126 |
| CSP (ms) | 91.6 ± 20.1* | 109.9 ± 18.5 | 120.1 ± 14.4 | 0.18 | 0.028 | 0.298 | 0.071 |
n, patient number; n.a., not available; HC, healthy controls; RBD, REM sleep behavior disorder; TRA-RBD, patients with RBD and abnormal TRODAT-1 SPECT; TRN-RBD, patients with RBD and normal TRODAT-1 SPECT; RMT, resting motor threshold; AMT, active motor threshold; MEP, motor-evoked potentials; MVC, maximal voluntary contraction; SICI, short interval intracortical inhibition; ICF, intracortical facilitation; CSP, contralateral silence period. *Significant difference between TRA-RBD and HC (Mann–Whitney U test; p < 0.05). †Significant difference among the three groups (Kruskal Wallis Test; p < 0.05).