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. 2023 May 24;14:1172199. doi: 10.3389/fendo.2023.1172199

Figure 2.

Figure 2

Effect of intraperitoneal administration of mPTD-BMP7 on pancreas function. (A) Ten micrograms of indocyanine green (ICG)-labeled mPTD-BMP7 was injected intraperitoneally, and the dissected major organs were assessed by ex vivo fluorescence imaging over time. (B) Quantitative analysis of the ex vivo fluorescence images of the pancreas and kidney. (C) Experimental schematics of streptozotocin (STZ)-induced diabetic mice. The diabetic condition was induced by an intraperitoneal injection of STZ (50 mg/kg) for 5 days consecutively, followed by an intraperitoneal injection of mPTD-BMP7 (0.5 mg/kg) twice per week. (D) Fasting glucose level was assessed over time for 16 weeks. Concentrations of insulin (E) and C-peptide (F) were measured in the extracted serum; these are reduced after mPTD-BMP7 administration. (G) mRNA levels of adult pancreatic markers (upper) and pancreatic developmental markers (lower) in STZ mice were attenuated after mPTD-BMP7 administration. (*P < 0.05; **P < 0.01; ***P < 0.001; versus control group. #P < 0.05; ##P < 0.01; ###P < 0.001; versus mPTD-BMP7 group).