Table 3.
Effect of mPTD-BMP7 assessed by clinical parameters in the animal models of diabetes.
| Control (n=5) |
STZ + Vehicle (n=7) |
STZ + mPTD-BMP7 (n=6) |
|
|---|---|---|---|
| Body weight (g) | 28.97 ± 0.63 | 21.09 ± 1.24 | 21.57 ± 2.26 |
| Kidney weight (mg) | 155.45 ± 17.56 | 185.69 ± 16.18 | 179.09 ± 29.60 |
| Kidney/body weight (mg/g) | 5.37 ± 0.66 | 8.80 ± 0.39 | 8.36 ± 1.39 |
| Blood glucose (mg/dL) | 181.20 ± 61.21 | 489.57 ± 144.00 | 437.17 ± 124.69 |
| HbA1c (%) | 5.92 ± 0.96 | 10.83 ± 1.43 | 9.60 ± 2.52 |
| Serum bilirubin (mg/dL) | 0.03 ± 0.02 | 0.07 ± 0.03* | 0.04 ± 0.02# |
| Serum Creatinine (mg/dL) | 0.18 ± 0.05 | 0.18 ± 0.05 | 0.13 ± 0.04 |
| Serum BUN (mg/dL) | 25.60 ± 5.37 | 36.43 ± 9.22 | 42.83 ± 17.02 |
| Urine Creatinine (mg/dL) | 50.42 ± 12.64 | 6.37 ± 0.47 | 10.46 ± 11.95 |
| 24-hr Urine Albumin (μg) | 6.60 ± 2.73 | 49.99 ± 23.74 | 39.47 ± 26.10 |
| UACR (μg/mg) | 16.05 ± 8.47 | 37.06 ± 10.79* | 31.60 ± 18.27# |
STZ, streptozotocin; mPTD-BMP7, protein transduction domain-fused BMP7 in micelle; BUN, blood urea nitrogen; UACR, urine albumin-creatinine ratio. *P < 0.05; versus control group. #P < 0.05; versus STZ + Vehicle group.