Table 5.
The top 10 enriched KEGG pathways.
| KEGG | Enriched shortest paths | Functions | Reference |
|---|---|---|---|
| PARKINSON DISEASE | 1213 | (1) T2DM and Parkinson Disease have shared pathological mechanism. (2) T2DM is a determinant of Parkinson Disease risk and progression. |
(76–78) |
| OXIDATIVE PHOSPHORYLATION | 1175 | Causing metabolic alterations at the organism level through producing energy-rich molecules like ATP. | (87) |
| ALZHEIMERS DISEASE | 1128 | (1) T2DM is modifiable risk factor for Alzheimer’s Disease. (2) Insulin resistance is a common mechanism between Alzheimer’s Disease and T2DM. |
(79, 80) |
| HUNTINGTONS DISEASE | 1115 | T2DM and Huntington’s Disease have shared treatment method. | (81) |
| LEISHMANIA INFECTION | 702 | Related to the immune system. | (82) |
| CARDIAC MUSCLE CONTRACTION | 357 | Related to insulin sensitivity and mitochondrial function. | (88) |
| TOLL LIKE RECEPTOR SIGNALING PATHWAY | 239 | Producing and releasing various inflammatory mediators and triggering immune response. | (83) |
| COLORECTAL CANCER | 163 | T2DM is the risk factor for colorectal cancer. | (84) |
| ADHERENS JUNCTION | 145 | Regulating insulin vesicle trafficking. | (85) |
| T CELL RECEPTOR SIGNALING PATHWAY | 84 | Related to immune system. | (86) |