Table 1. The main results of STC2 on breast cancer.

Author, year	Country	Materials	Outcome	Predictive value of STC2 expression in BC
BC: breast cancer; STC2: stanniocalcin 2; ER+: estrogen receptor-positive; EMT: epithelial to mesenchymal transition; DMFS: distant metastasis-free survival; RFS: recurrence-free survival; DSS: disease specific-survival; OS: overall survival; DFS: disease free-survival; NC: non-correlation
Hou et al., 2015	China	Human BC cell lines: MDA-MB-231, MDA-MB-231HM and MCF-7	Morphology, proliferation, migration, EMT, invasion, and apoptosis	NC
Jiang et al., 2019	China	50 cases of BC tissues and corresponding 50 cases of paracancer normal breast tissues	Expression, tumor size, lymph node metastasis, distant metastasis, and stages	NC
Law and Wong, 2010	China	The human BC cell lines: MCF-7	Proliferation	Good prognosis
Di et al., 2020	China	Human BC cell lines: MDA-MB-231 and T-47D; The healthy human breast epithelial cell lines: MCF-10A	Proliferation, invasion, metastasis, and migration	Poor prognosis
Raulic et al., 2008	Canada	The human breast cancer cell lines: T-47D, MCF-7, MDA-MB-435, MDA-MB-231 and MDA-MB-468	Expression, proliferation, and motility	NC
Jansen et al., 2015	Netherlands	201 patients with ER+	Resistance, and survival analysis	NC
Esseghir et al., 2007	United Kingdom	245 invasive breast carcinomastissue	Expression analysis, and survival analysis	Good prognosis
Todd et al., 2016	United Kingdom	BC cell lines: HCC1954, SkBr3, JIMT1, AU565, BT474, ZR75.30 and UACC812	Migration, invasion, survival analysis, and proliferation	Good prognosis
Parris et al., 2014	Sweden	97 primary invasive breast cancer patients	DMFS, RFS, OS, DFS, and DSS	NC
Coulson-Gilmer et al., 2018	United Kingdom	477 male BC cases	OS and DFS	Good prognosis