Table 1. Applications of two-dimensional materials-based nanozyme in biomedicine.

Material	Enzyme-like activity	Application	Reference
GO-COOH, GQDs	Oxidase, catalase, superoxide dismutase	Glucose detection, antioxidant protection	Song et al. 2010, Chong et al. 2016
V2O5 nanosheets	Glutathione peroxidase	Anti-HIV-1 infection	Singh et al. 2021
Black phosphorus nanosheets	Superoxide dismutase	Acute kidney injury therapy, neurodegenerative disorder therapy	Hou et al. 2020, Chen et al. 2018
2D transition metal chalcogenides	Superoxide dismutase, nitrate reductase	Sepsis treatment	Yim et al. 2020
Nb2C (MXene)	Superoxide dismutase	Radioprotectant	Ren et al. 2019
2D MOF	Catalase, peroxidase	H2O2 detection, glucose detection	Wang et al. 2016, Huang et al. 2017
NbSe2	Superoxide dismutase, nitrate reductase	Anti-inflammation	Miao et al. 2020
SnSe	Dehydrogenase	Dehydrogenation catalysis	Gao et al. 2020
Cu2MoS4	Oxidase, peroxidase	Antibacterial treatment	Shan et al. 2020