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. 2023 Jun 7;8:88. doi: 10.1038/s41541-023-00679-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Experiment scheme showing groups of C57BL/6 female mice injected with 10 μg of AgTRIO mRNA-LNP or control mRNA (Luc mRNA-LNP), and boosted twice, at two-week intervals. b Two weeks after each immunization, mice were bled. 1:2,500 and 1:12,500 dilutions of sera were examined for AgTRIO-specific IgG antibodies by ELISA using recombinant AgTRIO as the antigen. c 1:2,500 dilution of sera collected after the final were examined for AgTRIO-specific IgG antibodies against salivary gland extracts by ELISA. (Median ± IQR, p < 0.05 using the Mann Whitney U-test) d 1:2,500 dilution of sera were used to determine AgTRIO-specific IgG1, IgG2a and IgG2b. 1:500 dilution of sera were examined for AgTRIO specific IgG3 antibodies.