Table 1.
Paired-label biodistribution of [125I]MEGMIB-5F7GGC and iso-[131I]GMIB-PODS-5F7GGC in athymic mice without tumors.
| Percent injected dose per grama | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| 1 h | 4 h | 24 h | ||||
|
|
||||||
| tissue | 125I | 131I | 125I | 131I | 125I | 131I |
| Liver | 3.1 ± 0.4 | 5.2 ± 0.6 | 1.2 ± 0.2 | 0.7 ± 0.3 | 0.4 ± 0.1 | 0.1 ± 0.0 |
| Spleen | 1.4 ± 0.6 | 1.2 ± 0.5 | 0.7 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0.0 |
| Lungs | 2.4 ± 0.4 | 3.4 ± 1.2 | 1.2 ± 0.1 | 1.2 ± 0.4 | 0.3 ± 0.2 | 0.4 ± 0.3 |
| Heart | 0.4 ± 0.0 | 0.5 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Kidneys | 15.7 ± 1.3 | 36.3 ± 5.2 | 1.6 ± 0.2 | 1.9 ± 0.4 | 0.6 ± 0.1 | 0.2 ± 0.0 |
| Stomach | 0.6 ± 0.1 | 0.8 ± 0.3 | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Sm. Int. | 2.8 ± 0.3 | 4.3 ± 0.7 | 0.8 ± 0.1 | 0.9 ± 0.3 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Lg. Int. | 0.6 ± 0.1 | 0.5 ± 0.1 | 3.9 ± 0.4 | 6.4 ± 0.7 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Muscle | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.00 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Blood | 0.7 ± 0.5 | 0.8 ± 0.4 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Bone | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Brain | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Thyroid | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.4 | 0.1 ± 0.1 | 0.0 ± 0.0 | 0.2 ± 0.0 |
a:
%ID/g, mean ± SD, n=5