. Author manuscript; available in PMC: 2023 Jun 7.

Published in final edited form as: J Med Chem. 2022 Nov 11;65(22):15358–15373. doi: 10.1021/acs.jmedchem.2c01331

Table 2.

Paired-label biodistribution of iso-[¹³¹I]GMIB-PODS-5F7GGC and [¹²⁵I]MEGMIB-5F7GGC in athymic mice bearing HER2-positive BT474 xenografts.

Percent injected dose per gram^a

	1 h		4 h		24 h

tissue	¹³¹I	¹²⁵I	¹³¹I	¹²⁵I	¹³¹I	¹²⁵I
Liver	6.6 ± 1.9	1.5 ± 0.4	1.4 ± 0.2	0.5 ± 0.1	0.2 ± 0.1	0.1 ± 0.0
Spleen	0.6 ± 0.2	0.4 ± 0.2	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Lungs	2.4 ± 1.2	1.4 ± 0.3	1.0 ± 0.3	0.7 ± 0.2	0.1 ± 0.1	0.2 ± 0.1
Heart	0.5 ± 0.1	0.5 ± 0.2	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.1 ± 0.0
Kidneys	55.3 ± 14.1	16.2 ± 3.3	4.8 ± 0.3	2.9 ± 0.4	0.7 ± 0.2	1.2 ± 0.3
Stomach	0.8 ± 0.1	0.7 ± 0.2	1.8 ± 3.5	1.5 ± 3.0	0.1 ± 0.1	0.1 ± 0.1
Sm. Int.	5.6 ± 0.1	9.1 ± 1.7	3.1 ± 0.7	1.6 ± 0.7	0.1 ± 0.1	0.1 ± 0.0
Lg. Int.	0.4 ± 0.1	1.1 ± 0.4	12.8 ± 3.6	14.3 ± 2.6	0.4 ± 0.2	0.2 ± 0.1
Muscle	0.5 ± 0.4	0.7 ± 0.6	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Blood	0.8 ± 0.2	0.8 ± 0.2	0.1 ± 0.0	0.3 ± 0.0	0.0 ± 0.0	0.13 ± 0.0
Bone	1.2 ± 1.6	1.5 ± 1.9	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Brain	0.1 ± 0.0	0.1 ± 0.1	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Thyroid	0.1 ± 0.4	0.0 ± 0.6	0.2 ± 0.1	0.1 ± 0.1	0.2 ± 0.2	0.1 ± 0.1
Tumor	16.2 ± 4.9	13.7 ± 4.5	13.7 ± 4.1	12.1 ± 3.6	4.8 ± 1.5	5.7 ± 1.8

^a:

%ID/g, mean ± SD, n=5