. Author manuscript; available in PMC: 2023 Jun 7.

Published in final edited form as: J Med Chem. 2022 Nov 11;65(22):15358–15373. doi: 10.1021/acs.jmedchem.2c01331

Table 4.

Iso-[²¹¹At]AGMB-PODS-5F7GGC single-label biodistribution of in athymic mice bearing subcutaneous HER2-positive BT474 xenografts.

	Percent injected dose per gram^a

tissue	1 h	4 h	24 h^b

Liver	8.4 ± 1.3	2.8 ± 0.8	0.6 ± 0.1
Spleen	1.4 ± 0.5	1.1 ± 0.4	0.3 ± 0.1
Lungs	2.6 ± 0.7	1.7 ± 0.4	0.4 ± 0.1
Heart	0.8 ± 0.2	0.4 ± 0.1	0.2 ± 0.1
Kidneys	70.9 ± 12.0	11.6 ± 2.4	2.5 ± 0.2
Stomach	3.2 ± 1.2	4.9 ± 1.5	1.0 ± 0.3
Sm. Int.	5.1 ± 0.5	2.7 ± 1.9	0.4 ± 0.1
Lg. Int.	0.6 ± 0.1	12.6 ± 4.5	1.0 ± 0.4
Muscle	0.5 ± 0.3	0.3 ± 0.3	0.0 ± 0.1
Blood	0.7 ± 0.3	0.3 ± 0.1	0.1 ± 0.1
Bone	0.7 ± 0.3	0.5 ± 0.4	0.1 ± 0.1
Brain	0.1 ± 0.1	0.1 ± 0.0	0.0 ± 0.0
Thyroid	0.8 ± 0.3	1.2 ± 0.4	1.1 ± 0.5
Tumor	15.1 ± 3.3	20.5 ± 2.4^c	8.8 ± 0.8

^a:

%ID/g, mean ± SD, n=5

^b:

n=4

^c:

n=2