. Author manuscript; available in PMC: 2023 Jun 7.

Published in final edited form as: J Med Chem. 2022 Nov 11;65(22):15358–15373. doi: 10.1021/acs.jmedchem.2c01331

Table 5.

Paired-label biodistribution of iso-[¹²⁵I]GMIB-PODS-5F7GGC and [¹⁷⁷Lu]Lu-DOTA-PODS-5F7GGC in athymic mice bearing subcutaneous HER2-positive BT474 xenografts.

Percent injected dose per gram^a

	1 h		4 h		24 h

tissue	¹²⁵I	¹⁷⁷Lu	¹²⁵I	¹⁷⁷Lu	¹²⁵I	¹⁷⁷Lu
Liver	7.8 ± 2.6	1.3 ± 0.7	1.4 ± 0.4	0.6 ± 0.2	0.2 ± 0.1	0.4 ± 0.0
Spleen	0.6 ± 0.2	0.5 ± 0.2	0.1 ± 0.0	0.2 ± 0.1	0.0 ± 0.0	0.2 ± 0.1
Lungs	4.1 ± 2.6	1.7 ± 0.2	3.1 ± 1.3	1.6 ± 0.8	0.8 ± 0.9	0.4 ± 0.4
Heart	0.5 ± 0.2	0.6 ± 0.2	0.1 ± 0.0	0.3 ± 0.1	0.0 ± 0.0	0.2 ± 0.1
Kidneys	65.1 ± 20.0	73.6 ± 13.9	6.3 ± 1.2	64.8 ± 13.7	1.1 ± 0.2	40.8 ± 9.7
Stomach	1.4 ± 1.5	1.2 ± 1.7	0.4 ± 0.3	0.3 ± 0.2	0.0 ± 0.0	0.0 ± 0.0
Sm. Int.	5.1 ± 1.2	1.5 ± 1.3	2.9 ± 1.2	0.4 ± 0.2	0.1 ± 0.0	0.1 ± 0.0
Lg. Int.	0.5 ± 0.1	0.3 ± 0.1	11.1 ± 4.0	1.0 ± 0.2	0.3 ± 0.2	0.1 ± 0.0
Muscle	0.5 ± 0.1	0.5 ± 0.2	0.1 ± 0.0	0.1 ± 0.1	0.0 ± 0.0	0.1 ± 0.0
Blood	0.8 ± 0.2	1.6 ± 0.3	0.1 ± 0.1	0.6 ± 0.1	0.1 ± 0.1	0.3 ± 0.2
Bone	0.9 ± 0.5	0.9 ± 0.6	0.1 ± 0.0	0.2 ± 0.0	0.0 ± 0.0	0.0 ± 0.1
Brain	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Thyroid	0.2 ± 0.2	0.2 ± 0.2	0.1 ± 0.0	0.1 ± 0.1	0.1 ± 0.0	0.1 ± 0.1
Tumor	21.2 ± 8.4	15.9 ± 6.2	17.4 ± 2.3	14.4 ± 1.9	6.4 ± 1.7	8.5 ± 1.5

^a:

%ID/g, mean ± SD, n=5