FIGURE 14.

Crohn’s disease. Axial (a, b) and coronal (c) contrast enhanced CT images of the abdomen in a 45-year-old female reveal mesenteric fibrofatty proliferation in the right iliac fossa (curved white arrow), mesenteric lymph nodes (thin white arrow), thickening of the caecal wall with submucosal fat proliferation ([fat target sign] – thick white arrow) and prominent and straightened vasa recta ([Comb sign] – arrowheads). Photomicrograph of the ileal biopsy specimen (d) shows transmural infiltration of the ileum by inflammatory cells with loss of the villous architecture.