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. 2023 May 9;15(6):e16910. doi: 10.15252/emmm.202216910

Figure 5. Ascorbate and IACS‐010759 synergistically induce cell death of Myc‐overexpressing DLBCL cells in vitro .

Figure 5

The DLBCL cell lines DoHH2, SU‐DHL‐6, Karpas 422 and HBL‐1 were treated with the indicated concentrations of IACS‐010759 and ascorbate, and cell viability determined after 24 h.
  1. Live cell counts. n = 3 biological replicates; error bars: SD.
  2. Drug interaction landscapes and synergy scores, calculated according to the ZIP model: a positive ZIP score (> 10) signifies a synergistic interaction. The landscape identifies the doses at which the drugs either synergize (red) or antagonize each other (green)—the latter not observed here.
Source data are available online for this figure.