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. 2023 Jun 2;16(5):dmm049488. doi: 10.1242/dmm.049488

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Both long and short Endoglin isoforms rescue eng^−/− heart failure. (A) PCR genotyping example of established fli1a:engLong and fli1a:engshort transgenic lines. Amplicon size difference is due to exon 13 inclusion in endoglin short coding transcript. (B) Mutant phenotype frequency in clutches from, eng^+/−, Tg(fli1a:engLong) and eng^+/−, Tg(fli1a:engshort) with eng^+/− fish at 3 dpf. Total number of mutants over total number of fish analyzed is indicated above bars. (C) Genotype distribution frequency and associated survival in 5-month-old fish from crosses between eng^+/− and eng^+/−, Tg(fli1a:engLong) or eng^+/−, Tg(fli1a:engshort). Left column shows even transgene distribution among the different genotypes. Fish numbers are indicated above bars. Right column shows Kaplan–Meier representation of survival according to genotype and transgenic status. −/− versus −/−, Tg(fli1a:engLong) or Tg(fli1a:engshort), ***P<0.0001 [log-rank (Mantel–Cox) test].