Table 5.
Characteristics of the dominant virulence genes.
| Category | Gene | Alternative names | Designation(s) |
|---|---|---|---|
| CWAPa (surface exposed LPXTG cell wall-anchored proteins) or Fms (Efm surface proteins) | acm | fms8 (MSCRAMM) | adhesin of collagen from Efm |
| scm | fms10 (MSCRAMM) | second collagen adhesion of Efm | |
| PGC-3 cluster | ebpAfm | fms 1 | endocarditis- and biofilm-associated pili A (MSCRAMM) |
| ebpBfm | fms5 | endocarditis- and biofilm-associated pili B (MSCRAMM) | |
| ebpCfm | fms9 | endocarditis- and biofilm-associated pili C, pilB (MSCRAMM) | |
| srtC | biofilm production sortase gene (encoding sortase C; SrtC) | ||
| Endocarditis-specific antigen A | efaA | Manganese ABC superfamily and ATP binding cassette transporter | |
| Type III secretion Proteins | bopD | Biofilm formation | |
| Antiphagocytosis and capsular polysaccharide | cpsA | uppS | Di-trans,poly-cis-decaprenylcistransferase |
| cpsB | cdsA | Phosphatidate cytidylyltransferase |