Table 1.
Azithromycin solid dispersions formulation. N: wet grinding method, DM: solvent evaporation method, AZ: azithromycin, β-CD: β-cyclodextrin, PEG: polyethylene glycol, PVP: polyvinylpyrrolidone.
| No. | Formula | AZ:polymer ratio (w/w) | No. | Formula | AZ:polymer ratio (w/w) |
|---|---|---|---|---|---|
| 01 | N_1 | AZ:β-CD 1:1 | 13 | N_3 | AZ:PVP K30 1:4 |
| 02 | N_1.1 | AZ:β-CD 1:2 | 14 | N_3.1 | AZ:PVP K30 1:6 |
| 03 | N_1.2 | AZ:β-CD 1:3 | 15 | N_3.2 | AZ:PVP K30 1:8 |
| 04 | DM_1 | AZ:β-CD 1:1 | 16 | DM_3 | AZ:PVP K30 1:4 |
| 05 | DM_1.1 | AZ:β-CD 1:2 | 17 | DM_3.1 | AZ:PVP K30 1:6 |
| 06 | DM_1.2 | AZ:β-CD 1:3 | 18 | DM_3.2 | AZ:PVP K30 1:8 |
| 07 | N_2 | AZ:PEG 6000 1:4 | 19 | N_4 | AZ:Eudragit L100 1:4 |
| 08 | N_2.1 | AZ:PEG 6000 1:6 | 20 | N_4.1 | AZ:Eudragit L100 1:6 |
| 09 | N_2.2 | AZ:PEG 6000 1:8 | 21 | N_4.2 | AZ:Eudragit L100 1:8 |
| 10 | DM_2 | AZ:PEG 6000 1:4 | 22 | DM_4 | AZ:Eudragit L100 1:4 |
| 11 | DM_2.1 | AZ:PEG 6000 1:6 | 23 | DM_4.1 | AZ:Eudragit L100 1:6 |
| 12 | DM_2.2 | AZ:PEG 6000 1:8 | 24 | DM_4.2 | AZ:Eudragit L100 1:8 |